| L. MessiCentre-forward |  Inter Miami | 🇦🇷Argentina | 39 | 35 | 23 | 1.2 | 100▲62.3% | 15▲49% |
| D. BouangaCentre-forward |  Los Angeles FC | 🇬🇦Gabon | 31 | 26 | 8 | 4.1 | 78▲19.8% | 29▼13.9% |
| A. DreyerWinger |  San Diego | 🇩🇰Denmark | 28 | 23 | 17 | 7.7 | 75▲265.7%↩ | 41▼13.3%↩ |
| EvanderAttacking midfielder |  FC Cincinnati | 🇧🇷Brazil | 28 | 25 | 24 | 7.3 | 73▲12.6%↩ | 39▼11.4%↩ |
| S. SurridgeCentre-forward |  Nashville SC | 🏴England | 28 | 25 | 3 | 7 | 66▲59.1% | 37▼6% |
| P. MusaCentre-forward |  FC Dallas | 🇭🇷Croatia | 28 | 19 | 6 | 6.8 | 64▲21.6% | 36▼14.6% |
| P. ZinckernagelWinger |  Chicago Fire | 🇩🇰Denmark | 31 | 15 | 13 | 3.6 | 64▲270.9%↩ | 26±0% |
| M. OjedaCentre-forward |  Orlando City SC | 🇦🇷Argentina | 27 | 16 | 9 | 12.7 | 63▲90% | 41▼9.5% |
| B. WhiteWinger |  Vancouver Whitecaps | 🇺🇸USA | 30 | 18 | 2 | 4.5 | 62▲26.8% | 29▼18.6% |
| T. AllendeCentral midfielder | Inter Miami | 🇦🇷Argentina | 27 | 20 | 2 | 11.9 | 61 | 38▼37.8%↩ |
| D. JoveljićCentre-forward |  Sporting Kansas City | 🇷🇸Serbia | 26 | 18 | 3 | 12.9 | 60▲4.4%↩ | 42▼11.1%↩ |
| E. Choupo-MotingCentre-forward |  New York Red Bulls | 🇨🇲Cameroon | 37 | 17 | 4 | 1.1 | 59▲317%↩ | 14▼13.9%↩ |
| T. BariboCentre-forward |  Philadelphia Union | 🇮🇱Israel | 28 | 18 | 3 | 6.7 | 59▲90.9% | 36▼4.3% |
| S. BerhalterDefensive midfielder | Vancouver Whitecaps | 🇺🇸USA | 25 | 4 | 10 | 15.2 | 59▲109.6% | 49▲13.5% |
| A. MartínezCentre-forward |  New York City FC | 🇨🇷Costa Rica | 27 | 19 | 1 | 12.7 | 59▲27.7% | 41▼8.1% |
| H. MukhtarCentre-forward | Nashville SC | 🇩🇪Germany | 31 | 17 | 8 | 3.9 | 57▲25.7% | 28▼13.5% |
| K. DenkeyCentre-forward | FC Cincinnati | 🇹🇬Togo | 25 | 26 | 1 | 14.8 | 57▲90%↩ | 47▼14%↩ |
| Marco PasalicCentral midfielder | Orlando City SC | 🇭🇷Croatia | 25 | 12 | 5 | 14.9 | 57 | 48▼27.3%↩ |
| J. GlesnesCentre-back | Philadelphia Union | 🇳🇴Norway | 32 | 1 | 1 | 2.7 | 56▲73% | 22▼17.9% |
| H. CuypersCentre-forward | Chicago Fire | 🇧🇪Belgium | 29 | 19 | 2 | 5.7 | 56▲40.3% | 33▼7.2% |
| J. PereyraCentral midfielder |  Minnesota United FC | 🇦🇷Argentina | 27 | 7 | 9 | 12.9 | 56▲102.9%↩ | 41▼19.8%↩ |
| Carles GilCentral midfielder |  New England Revolution | 🇪🇸Spain | 33 | 10 | 9 | 2.3 | 56▲62.3% | 21▼7.8% |
| D. RossiCentre-forward |  Columbus Crew | 🇺🇾Uruguay | 28 | 16 | 4 | 6.9 | 54▲41.5% | 37▼15% |
| N. HarrielFull-back | Philadelphia Union | 🇺🇸USA | 25 | 2 | 0 | 13.3 | 54▲72.7% | 43±0% |
| M. DelgadoCentral midfielder | Los Angeles FC | 🇺🇸USA | 31 | 3 | 7 | 3.6 | 53▲40.4%↩ | 26▼15.7%↩ |
| D. MihailovićAttacking midfielder |  Colorado Rapids | 🇺🇸USA | 27 | 13 | 7 | 12.8 | 52▲5% | 41▼11.6% |
| C. ArangoCentre-forward |  San Jose Earthquakes | 🇨🇴Colombia | 31 | 13 | 3 | 3.7 | 52▼8.4%↩ | 26▼17.5%↩ |
| M. ArfstenDefensive midfielder | Columbus Crew | 🇺🇸USA | 25 | 5 | 6 | 14.7 | 51▲91.8% | 47▲0.6% |
| Pep BielWinger |  Charlotte | 🇪🇸Spain | 29 | 10 | 11 | 5.2 | 51▲310.4% | 30▼5.6% |
| A. RusnákAttacking midfielder |  Seattle Sounders | 🇸🇰Slovakia | 32 | 12 | 8 | 2.8 | 51▲9.7% | 23▼20.1% |
| L. BombinoFull-back | San Diego | 🇺🇸USA | 20 | 1 | 3 | 13 | 51 | 49 |
| E. ForsbergAttacking midfielder | New York Red Bulls | 🇸🇪Sweden | 34 | 11 | 8 | 1.7 | 51▲50.7% | 19±0% |
| J. TverskovCentral midfielder | San Diego | 🇩🇰Denmark | 33 | 2 | 8 | 2.3 | 50▲82.9%↩ | 21▲10.5%↩ |
| L. SuárezCentre-forward | Inter Miami | 🇺🇾Uruguay | 39 | 10 | 11 | 0.9 | 50▼20.9% | 12▲3.4% |
| E. LöwenDefensive midfielder |  St. Louis City | 🇩🇪Germany | 29 | 6 | 3 | 5.1 | 49▲36.6% | 30▼15.9% |
| Josef MartínezCentre-forward | San Jose Earthquakes | 🇻🇪Venezuela | 33 | 14 | 2 | 1.8 | 49▲23.4%↩ | 17▼21.7%↩ |
| C. EspinozaCentral midfielder | San Jose Earthquakes | 🇦🇷Argentina | 31 | 4 | 8 | 3.6 | 48▲29.9% | 26▼24.1% |
| J. McGlynnAttacking midfielder |  Houston Dynamo | 🇺🇸USA | 23 | 6 | 9 | 14.9 | 48▲68.7%↩ | 48▲2.1%↩ |
| P. OwusuCentre-forward |  CF Montreal | 🇩🇪Germany | 29 | 13 | 3 | 5.6 | 48▲58.3%↩ | 33▼5.5%↩ |
| Rafael NavarroCentre-forward | Colorado Rapids | 🇧🇷Brazil | 26 | 12 | 3 | 13.3 | 48±0% | 43▼9% |
| O. ValakariCentral midfielder | San Diego | 🇫🇮Finland | 26 | 5 | 8 | 14 | 47▲221.9%↩ | 45▲30.5%↩ |
| D. MusovskiCentre-forward | Seattle Sounders | 🇺🇸USA | 30 | 16 | 5 | 4 | 47▲719.3% | 26±0% |
| O. MakhanyaCentre-back | Philadelphia Union | 🇿🇦South Africa | 22 | 1 | 0 | 13.4 | 46 | 45 |
| R. LodCentral midfielder | Minnesota United FC | 🇫🇮Finland | 33 | 6 | 4 | 2.2 | 46±0% | 20▼21.1% |
| M. AlmirónCentral midfielder |  Atlanta United FC | 🇵🇾Paraguay | 32 | 6 | 4 | 3 | 46▲5033.3%↩ | 24▼28.8%↩ |
| H. LozanoWinger | San Diego | 🇲🇽Mexico | 31 | 11 | 9 | 3.4 | 46▲227.9%↩ | 24▼39%↩ |
| J. PaintsilWinger |  Los Angeles Galaxy | 🇬🇭Ghana | 28 | 10 | 2 | 6.1 | 46▼4.8% | 33▼20.8% |
| M. FofanaCentre-back | New England Revolution | 🇲🇱Mali | 28 | 0 | 1 | 6.3 | 46▲126.4%↩ | 34▼30.1%↩ |
| Sergi PalenciaFull-back | Los Angeles FC | 🇪🇸Spain | 30 | 1 | 2 | 4.5 | 45▲6.3% | 29▼11.3% |
| Beau LerouxCentral midfielder | San Jose Earthquakes | 🇺🇸USA | 22 | 5 | 3 | 13.1 | 44 | 47 |
| M. LabordaCentre-back | Vancouver Whitecaps | 🇺🇾Uruguay | 26 | 6 | 1 | 13.7 | 44▲86.9% | 44▲6% |
| Sergio BusquetsCentral midfielder | Inter Miami | 🇪🇸Spain | 38 | 0 | 8 | 1.1 | 44▲19.3% | 14▼14.6% |
| H. WolfAttacking midfielder | New York City FC | 🇦🇹Austria | 27 | 11 | 6 | 12.3 | 44▲38.5% | 39▼13.2% |
| J. OsorioDefensive midfielder |  Toronto FC | 🇨🇦Canada | 34 | 4 | 1 | 1.6 | 43▲106.2% | 17▼6.2% |
| W. ZahaAttacking midfielder | Charlotte | 🇨🇮Côte d'Ivoire | 33 | 10 | 5 | 2.2 | 43 | 21▼14.5%↩ |
| N. ByrneFull-back | Charlotte | 🏴England | 34 | 0 | 0 | 1.5 | 43▲15.2% | 16▼27.1% |
| J. HaakCentre-back | New York City FC | 🇺🇸USA | 24 | 2 | 4 | 13.1 | 42▲323.2% | 46▲17.6% |
| AntonyAttacking midfielder |  Portland Timbers | 🇧🇷Brazil | 24 | 7 | 7 | 13 | 42▲42.2% | 48▲5.1% |
| J. LukićCentral midfielder | Philadelphia Union | 🇷🇸Serbia | 24 | 2 | 2 | 13 | 42 | 45▲3.7%↩ |
| A. PellegrinoWinger | San Diego | 🇳🇴Norway | 36 | 7 | 4 | 1.4 | 42▲46.6%↩ | 15▲13.2%↩ |
| D. LunaAttacking midfielder |  Real Salt Lake | 🇺🇸USA | 22 | 9 | 3 | 12.2 | 41▲13.2% | 49±0% |
| C. RoldanDefensive midfielder | Seattle Sounders | 🇺🇸USA | 31 | 1 | 3 | 3.5 | 41▲26.2% | 25▼19.7% |
| O. WolffWinger |  Austin | 🇺🇸USA | 21 | 7 | 8 | 11.5 | 41▲100.5% | 50▲15.6% |
| T. ReamCentre-back | Charlotte | 🇺🇸USA | 38 | 0 | 0 | 1 | 41▲202.2% | 13▲28.9% |
| C. BentekeCentre-forward |  DC United | 🇧🇪Belgium | 35 | 9 | 3 | 1.4 | 40▼44% | 15▼22.4% |
| M. IloskiCentre-forward | Philadelphia Union | 🇺🇸USA | 27 | 13 | 6 | 11 | 40▲510.8%↩ | 35±0% |
| B. CeballosCentre-back | New England Revolution | 🇨🇴Colombia | 25 | 1 | 0 | 12.4 | 40▲1000%↩ | 43▲19.3%↩ |
| I. Toklomati GiornoCentre-forward | Charlotte | 🇮🇱Israel | 21 | 12 | 3 | 11.1 | 39 | 48▲29.9% |
| C. McVeyCentre-back | San Diego | 🇸🇪Sweden | 29 | 2 | 0 | 5.6 | 39▲7.4%↩ | 33▼2.7%↩ |
| E. PonceCentre-forward | Houston Dynamo | 🇦🇷Argentina | 29 | 10 | 1 | 5.3 | 39▲154.5% | 31▼1.6% |
| D. AyalaDefensive midfielder | Portland Timbers | 🇦🇷Argentina | 24 | 2 | 1 | 12.2 | 39▲61.3% | 44▲7.4% |
| É. OcampoFull-back | Vancouver Whitecaps | 🇨🇴Colombia | 22 | 2 | 0 | 11.6 | 39▲3810% | 47▲30.4% |
| D. Jean-JacquesCentral midfielder | Philadelphia Union | 🇭🇹Haiti | 26 | 3 | 2 | 12.2 | 39▲766.7% | 40▲15.7% |
| João KlaussCentre-forward | St. Louis City | 🇧🇷Brazil | 29 | 10 | 2 | 5 | 39▲72.8% | 29▼17.2% |
| L. MurielCentre-forward | Orlando City SC | 🇨🇴Colombia | 35 | 9 | 5 | 1.4 | 39▲57.6% | 15▲2.7% |
| I. VassilevCentral midfielder | Philadelphia Union | 🇺🇸USA | 25 | 6 | 3 | 12 | 39▲45.1%↩ | 44▼1.1%↩ |
| M. HartelAttacking midfielder | St. Louis City | 🇩🇪Germany | 30 | 9 | 4 | 4.6 | 39▲104.8% | 30▲3.5% |
| K. KahlinaGoalkeeper | Charlotte | 🇭🇷Croatia | 34 | 0 | 0 | 1.6 | 38▲11% | 17▼27% |
| D. FagundezCentral midfielder | Los Angeles Galaxy | 🇺🇾Uruguay | 31 | 6 | 2 | 3.3 | 38▲72.4% | 23▼12.7% |
| E. SeguraCentre-back | Los Angeles FC | 🇨🇴Colombia | 29 | 1 | 2 | 5.3 | 38▲110.6% | 31▼0.6% |
| D. ChambostDefensive midfielder | Columbus Crew | 🇫🇷France | 28 | 2 | 5 | 6.5 | 38▲310.9% | 35±0% |
| A. PereaDefensive midfielder | New York City FC | 🇺🇸USA | 25 | 3 | 2 | 11.7 | 38▲72.5% | 43▲4.4% |
| M. ReusAttacking midfielder | Los Angeles Galaxy | 🇩🇪Germany | 37 | 5 | 8 | 0.7 | 37▲332.6% | 9▲15% |
| M. DeslerCentral midfielder | Austin | 🇩🇰Denmark | 31 | 1 | 3 | 3.2 | 37▲527.1% | 23▲7.5% |
| J. MorrisCentre-forward | Seattle Sounders | 🇺🇸USA | 31 | 7 | 1 | 3.1 | 37▼24.4% | 22▼33.3% |
| W. TrappCentral midfielder | Minnesota United FC | 🇺🇸USA | 33 | 2 | 2 | 2.1 | 37▲32% | 19▼16.8% |
| R. VeselinovićCentre-back | Vancouver Whitecaps | 🇷🇸Serbia | 27 | 0 | 0 | 11.5 | 37▲56.8% | 38▼12.3% |
| A. YusufCentral midfielder | New England Revolution | 🇳🇬Nigeria | 26 | 2 | 1 | 11.5 | 37▲353.1% | 41▲17.7% |
| K. O'TooleFull-back | New York City FC | 🇺🇸USA | 27 | 1 | 1 | 11.4 | 37▲202.5% | 37▼14.1% |
| M. HerreraDefensive midfielder | Columbus Crew | 🇦🇷Argentina | 27 | 5 | 3 | 11.1 | 36▲29.7%↩ | 36▼25.4%↩ |
| A. MarkanichFull-back | Minnesota United FC | 🇺🇸USA | 26 | 10 | 1 | 11.3 | 36▲438.8%↩ | 40▲2.6%↩ |
| E. AtuestaCentral midfielder | Orlando City SC | 🇨🇴Colombia | 29 | 0 | 6 | 5.3 | 36▲1.1%↩ | 31▼14%↩ |
| P. BuchaDefensive midfielder | FC Cincinnati | 🇨🇿Czechia | 28 | 4 | 5 | 6.6 | 36▼10.9% | 35▼20.5% |
| T. BlackmonCentre-back | Vancouver Whitecaps | 🇺🇸USA | 29 | 2 | 1 | 5.3 | 36▲115% | 31▼9.6% |
| D. SealyAttacking midfielder | CF Montreal | 🇺🇸USA | 23 | 9 | 1 | 11.1 | 36▲600%↩ | 46▲18.8%↩ |
| Felipe AndradeFull-back | Houston Dynamo | 🇧🇷Brazil | 24 | 4 | 1 | 11.1 | 36▲624.5%↩ | 43▼25%↩ |
| Gabriel PecWinger | Los Angeles Galaxy | 🇧🇷Brazil | 25 | 7 | 3 | 11 | 35▼49.2% | 44▼13.9% |
| F. EscobarFull-back | Houston Dynamo | 🇦🇷Argentina | 31 | 2 | 2 | 3.1 | 35▲7.3% | 22▼19.5% |
| Y. TakaokaGoalkeeper | Vancouver Whitecaps | 🇯🇵Japan | 30 | 0 | 1 | 4.7 | 35▲104.7% | 30▼14.5% |
| D. GazdagAttacking midfielder | Columbus Crew | 🇭🇺Hungary | 30 | 6 | 5 | 4.5 | 35▼36.1%↩ | 29▼14.5%↩ |
