| L. MessiWinger | Inter Miami | 🇦🇷Argentina | 39 | 18 | 9 | 1.1 | 86▼13.8% | 13▼7.1% |
| H. LlorisGoalkeeper | Los Angeles FC | 🇫🇷France | 39 | 0 | 0 | 1 | 74▲163.7% | 13▼7.1% |
| P. MusaCentre-forward | FC Dallas | 🇭🇷Croatia | 28 | 16 | 2 | 6.8 | 73▲20.8% | 37▲3.6% |
| P. OwusuCentre-forward | CF Montreal | 🇩🇪Germany | 29 | 13 | 6 | 5.7 | 73▲52.5% | 33▲1.2% |
| GuilhermeWinger | Houston Dynamo | 🇧🇷Brazil | 31 | 12 | 5 | 4 | 72▲115.8%↩ | 29▼20.8%↩ |
| N. Fernández MercauWinger | New York City FC | 🇦🇷Argentina | 26 | 14 | 3 | 14.1 | 71▲278.7% | 45▲22% |
| EvanderWinger | FC Cincinnati | 🇧🇷Brazil | 28 | 12 | 8 | 6.9 | 70▲1.3% | 37▼2.9% |
| S. SurridgeCentre-forward | Nashville SC | 🏴England | 28 | 13 | 0 | 6.4 | 67▲1.8% | 33▼11% |
| P. JuddCentre-forward | San Jose Earthquakes | 🇺🇸USA | 27 | 11 | 2 | 12.6 | 66▲193.7% | 41▲24.2% |
| R. PorteousCentre-back | Los Angeles FC | 🏴Scotland | 27 | 0 | 0 | 12.1 | 65▲343.5% | 39▲22.5% |
| M. OjedaCentre-forward | Orlando City SC | 🇦🇷Argentina | 27 | 11 | 0 | 11.6 | 65▲2.9% | 39▼5.1% |
| Pep BielAttacking midfielder | Charlotte | 🇪🇸Spain | 29 | 10 | 6 | 5.9 | 64▲39.1% | 35▲18.7% |
| M. IngvartsenCentre-forward | San Diego | 🇩🇰Denmark | 30 | 11 | 3 | 4.4 | 63▲719.5% | 29▲42.5% |
| K. DenkeyCentre-forward | FC Cincinnati | 🇹🇬Togo | 25 | 11 | 2 | 14.6 | 63▲36.4% | 47▲4.7% |
| E. SeguraCentre-back | Los Angeles FC | 🇨🇴Colombia | 29 | 0 | 0 | 5.5 | 63▲66% | 32▲1.6% |
| T. BariboCentre-forward | DC United | 🇮🇱Israel | 28 | 12 | 0 | 6.5 | 63▲23.6%↩ | 35▲2.6%↩ |
| D. BouangaWinger | Los Angeles FC | 🇬🇦Gabon | 31 | 11 | 4 | 3.9 | 62▼18.9% | 28±0% |
| B. WhiteCentre-forward | Vancouver Whitecaps | 🇺🇸USA | 30 | 13 | 2 | 4.8 | 62▲36.5% | 32▲20.1% |
| A. DreyerAttacking midfielder | San Diego | 🇩🇰Denmark | 28 | 8 | 10 | 7.2 | 62▼16.9% | 38▼8.3% |
| B. SchwakeGoalkeeper | Nashville SC | 🇺🇸USA | 25 | 0 | 1 | 14.2 | 61 | 47 |
| Riqui PuigCentral midfielder | Los Angeles Galaxy | 🇪🇸Spain | 27 | 0 | 0 | 4.6 | 61▲72.2% | 25▼48.3% |
| E. Choupo-MotingCentre-forward | New York Red Bulls | 🇨🇲Cameroon | 37 | 3 | 1 | 0.3 | 59±0% | 4▼74.1% |
| A. MartínezCentre-forward | New York City FC | 🇨🇷Costa Rica | 27 | 19 | 1 | 12.8 | 59▲27.7% | 39▼12.8% |
| K. WagnerFull-back | Philadelphia Union | 🇩🇪Germany | 29 | 0 | 3 | 3 | 58±0% | 24▼26.6% |
| Rafael NavarroCentre-forward | Colorado Rapids | 🇧🇷Brazil | 26 | 10 | 3 | 14.2 | 58▲26% | 46▲10.3% |
| G. BerterameCentre-forward | Inter Miami | 🇦🇷Argentina | 27 | 7 | 4 | 11.9 | 58▲36.6%↩ | 38▼9.9%↩ |
| N. TafariFull-back | Los Angeles FC | 🇺🇸USA | 29 | 0 | 1 | 5.1 | 58▲87.9% | 31▲10% |
| J. HallWinger | New York Red Bulls | 🇺🇸USA | 18 | 9 | 3 | 11.8 | 56▲1066.7% | 56▲37.9% |
| M. IloskiCentre-forward | Philadelphia Union | 🇺🇸USA | 27 | 11 | 2 | 12.7 | 55▲39% | 41▲15.1% |
| S. SolansCentre-forward | Real Salt Lake | 🏳️ | 22 | 9 | 3 | 14.1 | 55 | 49 |
| K. KelsyCentre-forward | Portland Timbers | 🇻🇪Venezuela | 22 | 9 | 2 | 13.6 | 54▲126.8% | 46▲8.2% |
| P. ZinckernagelWinger | Chicago Fire | 🇩🇰Denmark | 31 | 5 | 7 | 3.6 | 54▼13.4% | 26▲3.1% |
| Felipe AndradeCentre-back | Houston Dynamo | 🇧🇷Brazil | 24 | 1 | 0 | 14.9 | 53▲87.6% | 46▲10.1% |
| T. AllendeCentral midfielder | Inter Miami | 🇦🇷Argentina | 27 | 0 | 0 | 5.4 | 53±0% | 29▼23.4% |
| M. WoledziCentre-back | Nashville SC | 🇬🇭Ghana | 25 | 2 | 0 | 13.9 | 53▲6.1%↩ | 45▲2.5%↩ |
| Antônio CarlosCentre-back | Houston Dynamo | 🇧🇷Brazil | 33 | 0 | 0 | 2.1 | 52▲540.7% | 16▲60.2% |
| É. OcampoFull-back | Vancouver Whitecaps | 🇨🇴Colombia | 22 | 2 | 1 | 14.9 | 51▲36.1% | 48▲3.6% |
| J. BondGoalkeeper | Houston Dynamo | 🏴England | 33 | 0 | 0 | 2.3 | 50▲122% | 21▲25.6% |
| Son Heung-MinWinger | Los Angeles FC | 🇰🇷Korea Republic | 34 | 4 | 8 | 1.6 | 50▲53.7% | 17▲55.4% |
| O. ValakariAttacking midfielder | San Diego | 🇫🇮Finland | 27 | 4 | 3 | 11 | 50▲48.4% | 39▼4.2% |
| T. WernerCentre-forward | San Jose Earthquakes | 🇩🇪Germany | 30 | 5 | 3 | 3.8 | 49 | 24▼19.8%↩ |
| A. ReschCentre-back | Houston Dynamo | 🏳️ | 23 | 1 | 0 | 14.4 | 49 | 46 |
| A. MehmetiCentral midfielder | New York Red Bulls | 🇺🇸USA | 17 | 1 | 3 | 10.3 | 49 | 53 |
| T. MüllerAttacking midfielder | Vancouver Whitecaps | 🇩🇪Germany | 36 | 7 | 4 | 1.6 | 49▲106.4% | 17▲60.2% |
| R. LewandowskiCentre-forward | Chicago Fire | 🇵🇱Poland | 38 | 4 | 1 | 0.7 | 48±0% | 5▼68.8%↩ |
| Carles GilAttacking midfielder | New England Revolution | 🇪🇸Spain | 33 | 8 | 4 | 2.3 | 48±0% | 21▼0.5% |
| R. De PaulAttacking midfielder | Inter Miami | 🇦🇷Argentina | 32 | 4 | 6 | 2.6 | 47▲159.7% | 21▲32.3% |
| D. JoveljićCentre-forward | Seattle Sounders | 🇷🇸Serbia | 27 | 10 | 1 | 5.6 | 47▼21.2%↩ | 38▲0.5%↩ |
| W. CarmonaAttacking midfielder | CF Montreal | 🇻🇪Venezuela | 23 | 4 | 2 | 8.1 | 47▲162.9%↩ | 44▲5.7%↩ |
| C. EspinozaWinger | Nashville SC | 🇦🇷Argentina | 31 | 3 | 9 | 3.2 | 47▲31.9%↩ | 23▼11%↩ |
| D. LovitzCentre-back | Nashville SC | 🇺🇸USA | 35 | 0 | 1 | 1.4 | 47▲40.4% | 16▼7.1% |
| Y. TakaokaGoalkeeper | Vancouver Whitecaps | 🇯🇵Japan | 30 | 0 | 1 | 4.7 | 47▲33.1% | 30▼1% |
| M. MbokaziCentre-back | Chicago Fire | 🇿🇦South Africa | 20 | 0 | 0 | 6.9 | 46▲82%↩ | 44▲80.4%↩ |
| V. JanssenCentre-forward | Portland Timbers | 🇳🇱Netherlands | 32 | 0 | 0 | 0.8 | 46±0% | 30▲2.4%↩ |
| H. MukhtarCentre-forward | Nashville SC | 🇩🇪Germany | 31 | 10 | 6 | 3.8 | 46▼20% | 25▼9.7% |
| A. CubasDefensive midfielder | Vancouver Whitecaps | 🇵🇾Paraguay | 30 | 0 | 2 | 4.4 | 46▲69.7% | 27▲3.1% |
| A. MiranchukAttacking midfielder | Atlanta United FC | 🇷🇺Russia | 30 | 5 | 6 | 4.5 | 46▲10.8% | 29▲1.4% |
| L. SuárezCentre-forward | Inter Miami | 🇺🇾Uruguay | 39 | 10 | 2 | 0.8 | 46▲1.1% | 9▼19.6% |
| K. YeboahCentre-forward | Minnesota United FC | 🇮🇹Italy | 26 | 11 | 1 | 12.9 | 46▲59.2% | 42▲5% |
| N. TsakirisAttacking midfielder | San Jose Earthquakes | 🇺🇸USA | 21 | 2 | 4 | 8 | 45▲682.8% | 47▲18.9% |
| Sergi PalenciaCentre-back | Los Angeles FC | 🇪🇸Spain | 30 | 1 | 0 | 3.4 | 45±0% | 22▼22.3% |
| D. Jean-JacquesCentral midfielder | Philadelphia Union | 🇭🇹Haiti | 26 | 3 | 1 | 13.1 | 45▲22.2% | 42▲6.9% |
| T. MuyumbaCentral midfielder | Atlanta United FC | 🇫🇷France | 29 | 4 | 0 | 5.3 | 45▲223.7% | 31▲26.9% |
| P. AaronsonAttacking midfielder | Colorado Rapids | 🇺🇸USA | 23 | 4 | 5 | 12.6 | 45▲533.8% | 50▲34.7% |
| M. LabordaFull-back | Vancouver Whitecaps | 🇺🇾Uruguay | 26 | 3 | 2 | 13.9 | 45▲19.6% | 46▲9.5% |
| J. PalaciosFull-back | Nashville SC | 🇨🇴Colombia | 32 | 1 | 1 | 2.5 | 44▲90.9% | 20▲9.9% |
| Josef MartínezCentre-forward | Columbus Crew | 🇻🇪Venezuela | 33 | 0 | 0 | 0.5 | 44±0% | 11▼32.3%↩ |
| L. LangoniWinger | New England Revolution | 🇦🇷Argentina | 24 | 3 | 6 | 10 | 44▲101.4% | 43▼0.7% |
| A. OjedaAttacking midfielder | New York City FC | 🇦🇷Argentina | 22 | 5 | 6 | 13.7 | 44▲110% | 50▲19.1% |
| M. ReusAttacking midfielder | Los Angeles Galaxy | 🇩🇪Germany | 37 | 4 | 6 | 0.9 | 44▲38.2% | 12▲43.2% |
| P. BuchaAttacking midfielder | FC Cincinnati | 🇨🇿Czechia | 28 | 5 | 4 | 6.7 | 44▲25.6% | 36▲5.8% |
| D. EdelmanCentral midfielder | St. Louis City | 🇺🇸USA | 23 | 2 | 2 | 13.4 | 44▲96%↩ | 49▲16.8%↩ |
| G. DorseyCentral midfielder | Orlando City SC | 🇺🇸USA | 27 | 3 | 1 | 11.5 | 43▲34.2%↩ | 37▼2.1%↩ |
| C. DurkinDefensive midfielder | St. Louis City | 🇺🇸USA | 26 | 2 | 0 | 11.7 | 43▲215.3% | 42▲29.6% |
| M. MoralezAttacking midfielder | New York City FC | 🇦🇷Argentina | 39 | 1 | 6 | 0.7 | 43▼1.4% | 10▼22.4% |
| B. EmboloCentre-forward | Atlanta United FC | 🇨🇭Switzerland | 29 | 9 | 3 | 8.1 | 43▲18.1%↩ | 53▼19.3%↩ |
| M. DelgadoCentral midfielder | Los Angeles FC | 🇺🇸USA | 31 | 2 | 2 | 3.6 | 43▲1.4% | 25▼1.2% |
| L. JovanovićCentre-forward | San Jose Earthquakes | 🇦🇺Australia | 21 | 0 | 0 | 6.2 | 43▲9%↩ | 37▲61.2%↩ |
| M. DuahCentre-back | San Diego | 🇬🇭Ghana | 21 | 0 | 1 | 12.1 | 43▲305.7% | 46▲6.7% |
| CasemiroCentral midfielder | Inter Miami | 🇧🇷Brazil | 34 | 1 | 0 | 1.1 | 43±0% | 6▼80.6%↩ |
| M. AlmirónWinger | Atlanta United FC | 🇵🇾Paraguay | 32 | 3 | 4 | 2.5 | 42▼6.8% | 20▼14.5% |
| H. LozanoWinger | Los Angeles Galaxy | 🇲🇽Mexico | 31 | 1 | 0 | 1.2 | 42±0% | 22▼8.1%↩ |
| T. JohnsonCentre-back | Vancouver Whitecaps | 🇺🇸USA | 21 | 0 | 0 | 13.6 | 42▲45% | 49▲7.2% |
| L. EnnaliCentral midfielder | Houston Dynamo | 🇩🇪Germany | 24 | 3 | 2 | 11.9 | 42▲205.1% | 51▲36.1% |
| K. VeldeWinger | Portland Timbers | 🇳🇴Norway | 26 | 5 | 6 | 13.2 | 42▲262.6% | 43▲21.4% |
| W. Frederick IICentral midfielder | Colorado Rapids | 🇺🇸USA | 22 | 2 | 2 | 10 | 41 | 46▲32.5% |
| J. RuvalcabaCentre-forward | New York Red Bulls | 🇲🇽Mexico | 25 | 7 | 0 | 12 | 41▲81.9%↩ | 44▼11.9%↩ |
| O. WolffDefensive midfielder | Sporting Kansas City | 🇺🇸USA | 21 | 0 | 0 | 6.1 | 41±0% | 37▼26.6%↩ |
| H. WolfAttacking midfielder | New York City FC | 🇦🇹Austria | 27 | 5 | 2 | 9.8 | 41▼6.2% | 38▼2.8% |
| T. JacobCentral midfielder | Atlanta United FC | 🇦🇷Argentina | 22 | 3 | 1 | 14.2 | 41▲335.5%↩ | 45▲1.1%↩ |
| R. HollingsheadCentre-back | Los Angeles FC | 🇺🇸USA | 35 | 1 | 0 | 1.3 | 40▲18.5% | 13▼13.5% |
| L. BombinoFull-back | San Diego | 🇺🇸USA | 20 | 1 | 1 | 8.2 | 40▼8.6% | 43▼10.3% |
| J. PaintsilAttacking midfielder | Los Angeles Galaxy | 🇬🇭Ghana | 28 | 5 | 3 | 6.2 | 40▲10.7% | 33▲7.2% |
| A. O'NeillDefensive midfielder | New York City FC | 🇦🇺Australia | 28 | 0 | 1 | 3.9 | 40▲189.2% | 30±0% |
| L. SanabriaDefensive midfielder | Los Angeles Galaxy | 🇺🇾Uruguay | 22 | 2 | 1 | 10.7 | 40▲362.1% | 44▲15.6% |
| D. TurgemanCentre-forward | New England Revolution | 🇮🇱Israel | 22 | 6 | 4 | 13.3 | 40▲372.9% | 49▲17.5% |
| C. McVeyCentre-back | San Diego | 🇸🇪Sweden | 29 | 1 | 0 | 4.9 | 40▲2% | 29▼13.1% |
| A. RusnákAttacking midfielder | Seattle Sounders | 🇸🇰Slovakia | 32 | 3 | 7 | 2.7 | 40▼17% | 22▼1.8% |
| S. BecherCentre-forward | St. Louis City | 🇺🇸USA | 27 | 6 | 4 | 12.3 | 40▲144.2% | 40▲26.4% |
| A. YusufCentral midfielder | New England Revolution | 🇳🇬Nigeria | 26 | 5 | 1 | 13.2 | 40▲8.2% | 41±0% |