| S. DavisCentral midfielder | Nashville SC | 🇺🇸USA | 33 | 0 | 0 | 0 | 0.5 | 0▼100% | 7▼69.6% |
| S. DonovanCentral midfielder | Sporting Kansas City | 🏳️ | 18 | 1 | 0 | 0 | 4.8 | 0 | 35 |
| S. FarhiCentre-forward | Colorado Rapids | 🇮🇱Israel | 20 | 3 | 0 | 0 | 5.7 | 22±0% | 44±0% |
| S. FreiGoalkeeper | Seattle Sounders | 🇺🇸USA | 40 | 28 | 0 | 0 | 1.1 | 22▼41.3% | 14▲11.4% |
| S. GidiDefensive midfielder | FC Cincinnati | 🇬🇭Ghana | 22 | 27 | 0 | 1 | 7.9 | 29▲232.2% | 44▲12.5% |
| S. GomezAttacking midfielder | Seattle Sounders | 🇺🇸USA | 20 | 17 | 2 | 2 | 6.9 | 8 | 38 |
| S. HawkinsCentre-back | Seattle Sounders | 🇺🇸USA | 20 | 15 | 1 | 0 | 7.9 | 14▲7100% | 40▲8.1% |
| S. HeftiFull-back | DC United | 🇨🇭Switzerland | 29 | 26 | 2 | 2 | 6.2 | 38▲101.1%↩ | 35▼31.1%↩ |
| S. IbeaghaCentre-back | FC Dallas | 🇺🇸USA | 34 | 30 | 1 | 1 | 1.4 | 19▲1.1% | 15▼13.2% |
| S. JimenezDefensive midfielder | FC Cincinnati | 🇺🇸USA | 19 | 1 | 0 | 0 | 5.4 | 0▼66.7% | 36▼0.6% |
| S. JohnsonGoalkeeper | DC United | 🇺🇸USA | 37 | 30 | 0 | 0 | 1 | 16▲45.5%↩ | 13▲1.5%↩ |
| S. JunquaFull-back | Real Salt Lake | 🇺🇸USA | 29 | 21 | 0 | 1 | 2.5 | 8▼48.1% | 25▼6.8% |
| S. KitaharaCentral midfielder | Seattle Sounders | 🇺🇸USA | 23 | 0 | 0 | 0 | 6.4 | 0 | 33▼8.7% |
| S. KoneDefensive midfielder | New York Red Bulls | 🏳️ | 19 | 4 | 0 | 0 | 5.5 | 2 | 37 |
| S. KowalczykDefensive midfielder | Houston Dynamo | 🇵🇱Poland | 28 | 29 | 1 | 1 | 3.5 | 19▼32.7% | 32▼25.9% |
| S. KryvtsovCentre-back | Inter Miami | 🇺🇦Ukraine | 35 | 0 | 0 | 0 | 0.3 | 0▼100% | 6▼69.8% |
| S. LobzhanidzeWinger | Real Salt Lake | 🇬🇪Georgia | 31 | 16 | 2 | 2 | 2.8 | 19▲17.7%↩ | 17▼19.7%↩ |
| S. MohammedAttacking midfielder | Nashville SC | 🇬🇭Ghana | 23 | 20 | 4 | 1 | 8 | 14 | 40▲17.4%↩ |
| S. MooreFull-back | FC Dallas | 🇺🇸USA | 30 | 29 | 1 | 2 | 5.5 | 26▲2.4% | 32▲2.3% |
| S. MoralesCentral midfielder | Inter Miami | 🇺🇸USA | 19 | 2 | 0 | 0 | 5.5 | 0±0% | 36▲0.8% |
| S. MoreiraCentre-back | Columbus Crew | 🇫🇷France | 32 | 27 | 0 | 0 | 2.4 | 14▼11.8% | 21▼1% |
| S. MorenoWinger | FC Dallas | 🇨🇴Colombia | 26 | 25 | 3 | 3 | 7.2 | 18▼22.4%↩ | 38±0% |
| S. NealisCentre-back | DC United | 🇺🇸USA | 29 | 12 | 0 | 0 | 2.2 | 6▼76.6%↩ | 22▼20.7%↩ |
| S. O'NeillCentre-back | Toronto FC | 🇺🇸USA | 33 | 0 | 0 | 0 | 0.5 | 0▼100% | 7▼67% |
| S. OregelCentral midfielder | Chicago Fire | 🇺🇸USA | 21 | 10 | 0 | 0 | 6.3 | 1▼92.2% | 36▼18% |
| S. PietteDefensive midfielder | CF Montreal | 🇨🇦Canada | 31 | 19 | 0 | 0 | 1.7 | 13▼8.1% | 18▼8.3% |
| S. ReidCentre-forward | Sporting Kansas City | 🇯🇲Jamaica | 18 | 19 | 0 | 1 | 5.3 | 0▼100%↩ | 37▼9.2%↩ |
| S. RicheyGoalkeeper | Chicago Fire | 🇺🇸USA | 34 | 0 | 0 | 0 | 0.3 | 0▼100% | 6▼62.1% |
| S. RodríguezAttacking midfielder | Columbus Crew | 🇺🇾Uruguay | 26 | 7 | 2 | 2 | 7.6 | 20±0% | 52▼13.4%↩ |
| S. RogersCentre-back | Chicago Fire | 🇺🇸USA | 27 | 8 | 0 | 0 | 5.3 | 6▼56.8% | 29▼11.7% |
| S. SakaiCentre-back | New York Red Bulls | 🇯🇵Japan | 19 | 0 | 0 | 0 | 5.4 | 0 | 36 |
| S. SolansCentre-forward | Real Salt Lake | 🏳️ | 22 | 28 | 12 | 3 | 14.1 | 51 | 48 |
| S. SpieringsDefensive midfielder | Real Salt Lake | 🇳🇱Netherlands | 30 | 21 | 1 | 1 | 3.6 | 28▲55.4%↩ | 23▲6.6%↩ |
| S. SuárezCentre-back | New England Revolution | 🇺🇸USA | 21 | 14 | 0 | 0 | 5.6 | 9 | 33 |
| S. SurridgeCentre-forward | Nashville SC | 🏴England | 28 | 24 | 17 | 1 | 6.5 | 51▼22.4% | 33▼11% |
| S. VasquezDefensive midfielder | Los Angeles FC | 🇪🇨Ecuador | 22 | 4 | 0 | 0 | 6.5 | 2 | 36 |
| S. VinesCentre-back | San Diego | 🇺🇸USA | 27 | 3 | 0 | 0 | 4.7 | 2▼76.6%↩ | 28▼14.3%↩ |
| S. ZawadzkiDefensive midfielder | Columbus Crew | 🇺🇸USA | 26 | 29 | 0 | 1 | 8.9 | 22▼29.6% | 41▲4.8% |
| Sal OlivasCentre-forward | Philadelphia Union | 🇺🇸USA | 20 | 1 | 0 | 0 | 5.7 | 0 | 36±0% |
| Samuel SarverCentre-forward | FC Dallas | 🇺🇸USA | 23 | 19 | 3 | 1 | 7.9 | 12▲202.4% | 41▲13.3% |
| Sergi PalenciaFull-back | Los Angeles FC | 🇪🇸Spain | 30 | 15 | 1 | 1 | 3.2 | 21▼53.6% | 22▼25.1% |
| Sergi RobertoCentral midfielder | Los Angeles Galaxy | 🇪🇸Spain | 34 | 8 | 0 | 1 | 0.6 | 1▼80.6%↩ | 6▼59.2%↩ |
| Sergio SantosWinger | Atlanta United FC | 🇧🇷Brazil | 32 | 8 | 0 | 0 | 0.8 | 0▼100%↩ | 11▼19.7%↩ |
| Seung-jae YooCentral midfielder | Los Angeles FC | 🇰🇷South Korea | 18 | 1 | 0 | 0 | 5.8 | 0 | 42 |
| Shane DonovanCentral midfielder | Sporting Kansas City | 🇺🇸USA | 19 | 1 | 0 | 0 | 5.1 | 0 | 34 |
| Son Heung-MinWinger | Los Angeles FC | 🇰🇷Korea Republic | 34 | 28 | 7 | 12 | 1.6 | 50▲51.8% | 17▲55.4% |
| Stefan ChirilaCentral midfielder | FC Cincinnati | 🇺🇸USA | 19 | 4 | 0 | 0 | 5.4 | 0 | 36 |
| T. AllendeCentral midfielder | Inter Miami | 🇦🇷Argentina | 27 | 9 | 0 | 0 | 5.2 | 3▼94.1% | 29▼24.9% |
| T. BariboCentre-forward | DC United | 🇮🇱Israel | 28 | 23 | 16 | 1 | 6.6 | 52▲3.1%↩ | 35▲0.6%↩ |
| T. BarlowCentre-forward | FC Cincinnati | 🇺🇸USA | 31 | 28 | 8 | 2 | 2.9 | 25▲195.2%↩ | 20▲24.4%↩ |
| T. BaumgartlCentre-back | St. Louis City | 🇩🇪Germany | 30 | 30 | 1 | 0 | 3.8 | 22▲28.7% | 29▲30% |
| T. BeasonCentre-back | New England Revolution | 🇺🇸USA | 29 | 8 | 0 | 0 | 2 | 0▼98.7% | 20▼28.4% |
| T. BlackmonCentre-back | Vancouver Whitecaps | 🇺🇸USA | 30 | 28 | 1 | 0 | 4.5 | 42▲47.7% | 30▲16.6% |
| T. BoothCentre-forward | Real Salt Lake | 🇺🇸USA | 25 | 3 | 0 | 0 | 5.9 | 4±0% | 55±0% |
| T. BoydWinger | Los Angeles FC | 🇺🇸USA | 31 | 25 | 1 | 2 | 1.5 | 13▲456.5%↩ | 19▲32.2%↩ |
| T. ChancalayWinger | Minnesota United FC | 🇦🇷Argentina | 27 | 30 | 4 | 3 | 8.2 | 28▲53%↩ | 36▲9.5%↩ |
| T. CorbeanuWinger | Toronto FC | 🇨🇦Canada | 24 | 17 | 3 | 5 | 7.8 | 13▼55% | 39▼12.1% |
| T. D'AvillaCentral midfielder | Chicago Fire | 🇨🇮Côte d'Ivoire | 23 | 28 | 1 | 0 | 8.1 | 27▲19.9% | 43▲5.4% |
| T. ElgersmaWinger | Los Angeles Galaxy | 🏳️ | 21 | 7 | 1 | 0 | 6.5 | 3 | 39 |
| T. GrayCentre-back | New York City FC | 🇯🇲Jamaica | 24 | 26 | 1 | 1 | 8.2 | 31▲5.5% | 45▲7.2% |
| T. HabrouneCentral midfielder | Columbus Crew | 🇺🇸USA | 20 | 28 | 4 | 3 | 11.7 | 40▲206.1% | 48▲15.6% |
| T. HadebeCentre-back | FC Cincinnati | 🇿🇼Zimbabwe | 31 | 16 | 0 | 0 | 1.4 | 2▼92.3% | 18▼0.6% |
| T. HasalGoalkeeper | Los Angeles FC | 🇨🇦Canada | 27 | 3 | 0 | 0 | 5.2 | 5 | 29▲5.9% |
| T. JacobCentral midfielder | Atlanta United FC | 🇦🇷Argentina | 22 | 26 | 3 | 2 | 13.3 | 44▲377.4%↩ | 47▲5.7%↩ |
| T. JohnsonCentre-back | Vancouver Whitecaps | 🇺🇸USA | 21 | 28 | 0 | 1 | 13.7 | 47▲60.1% | 49▲7.7% |
| T. KarumanchiDefensive midfielder | Columbus Crew | 🏳️ | 23 | 10 | 0 | 0 | 6.9 | 6 | 37 |
| T. Ku-DiPietroDefensive midfielder | Colorado Rapids | 🇺🇸USA | 24 | 4 | 0 | 0 | 6.2 | 1▼93.5% | 34▼12.2% |
| T. MeliaGoalkeeper | Sporting Kansas City | 🇺🇸USA | 40 | 0 | 0 | 0 | 0.1 | 0▼100% | 2▼79.5% |
| T. MillerGoalkeeper | Charlotte | 🇺🇸USA | 33 | 3 | 0 | 0 | 0.7 | 4 | 10▼30.8%↩ |
| T. MoshobaneCentre-forward | Charlotte | 🇿🇦South Africa | 32 | 10 | 0 | 1 | 0.8 | 5 | 12 |
| T. MüllerAttacking midfielder | Vancouver Whitecaps | 🇩🇪Germany | 37 | 23 | 9 | 6 | 0.9 | 46▲96.6% | 17▲181.7% |
| T. MuyumbaCentral midfielder | Atlanta United FC | 🇫🇷France | 29 | 30 | 4 | 1 | 5.2 | 48▲243.2% | 31▲28.5% |
| T. NtsabelengCentral midfielder | FC Dallas | 🇿🇦South Africa | 28 | 13 | 0 | 1 | 3.1 | 16▲8.4% | 28▼15.8% |
| T. OstrákAttacking midfielder | St. Louis City | 🇨🇿Czechia | 26 | 7 | 2 | 0 | 6.4 | 4▼79.2% | 33▼1.2% |
| T. ParkerCentre-back | New York Red Bulls | 🇺🇸USA | 33 | 13 | 0 | 0 | 0.7 | 2▼84.2% | 10▼9.2% |
| T. PearceDefensive midfielder | St. Louis City | 🇺🇸USA | 19 | 2 | 0 | 0 | 5.7 | 1 | 37 |
| T. ReamCentre-back | Charlotte | 🇺🇸USA | 39 | 21 | 0 | 1 | 0.8 | 14▼60.5% | 10▼6.4% |
| T. RomeroGoalkeeper | New York City FC | 🇸🇻El Salvador | 25 | 1 | 0 | 0 | 6.1 | 5▲92% | 35▲3% |
| T. RosboroughCentral midfielder | New York Red Bulls | 🇺🇸USA | 18 | 5 | 0 | 0 | 5.2 | 0 | 37 |
| T. SegoviaAttacking midfielder | Inter Miami | 🇻🇪Venezuela | 23 | 26 | 3 | 8 | 10.4 | 42▲37.5% | 48▲7.9% |
| T. SmithCentre-back | New England Revolution | 🇿🇦South Africa | 21 | 3 | 0 | 0 | 9.3 | 1 | 55 |
| T. SpicerWinger | Orlando City SC | 🇹🇹Trinidad and Tobago | 25 | 22 | 5 | 1 | 7.2 | 25▲33%↩ | 40▲1.8%↩ |
| T. SzewczykGoalkeeper | New York Red Bulls | 🇺🇸USA | 17 | 0 | 0 | 0 | 4.8 | 0 | 36 |
| T. TillmanCentral midfielder | Los Angeles FC | 🇩🇪Germany | 27 | 19 | 1 | 2 | 6.5 | 27▲9.8% | 36▼4.3% |
| T. TotlandFull-back | St. Louis City | 🇳🇴Norway | 27 | 26 | 3 | 4 | 7.3 | 15▲21.4% | 41▲41.6% |
| T. WernerCentre-forward | San Jose Earthquakes | 🇩🇪Germany | 30 | 18 | 5 | 4 | 3.7 | 30 | 24▼20.8%↩ |
| T. WilliamsCentre-back | Nashville SC | 🇺🇸USA | 22 | 1 | 0 | 0 | 6.2 | 1▼86.1%↩ | 35▼9.7%↩ |
| Talles MagnoWinger | New York City FC | 🇧🇷Brazil | 24 | 18 | 2 | 2 | 7.5 | 15▲5.6%↩ | 40▼31.3%↩ |
| ThayllonWinger | Los Angeles FC | 🇧🇷Brazil | 20 | 1 | 0 | 0 | 5.8 | 0 | 36 |
| Thiago MartinsCentre-back | New York City FC | 🇧🇷Brazil | 31 | 26 | 0 | 0 | 2.3 | 16▼52.9% | 23▼4.5% |
| TiagoWinger | Orlando City SC | 🇧🇷Brazil | 21 | 20 | 1 | 1 | 6.9 | 11▼29.9%↩ | 40▼40.1%↩ |
| Tristan BrownDefensive midfielder | Columbus Crew | 🇺🇸USA | 19 | 6 | 0 | 0 | 5.5 | 1 | 37 |
| Tyger SmallsWinger | Charlotte | 🏴England | 24 | 15 | 0 | 0 | 6.4 | 0 | 35▲2.1% |
| V. BezerraCentre-forward | Chicago Fire | 🇺🇸USA | 26 | 0 | 0 | 0 | 5.4 | 0 | 29 |
| V. JanssenCentre-forward | Portland Timbers | 🇳🇱Netherlands | 32 | 10 | 4 | 0 | 1.7 | 9▼80.1%↩ | 13▼55.8%↩ |
| V. LoturiCentral midfielder | CF Montreal | 🇨🇦Canada | 25 | 29 | 1 | 1 | 9.2 | 32▲7% | 43▲1% |
| V. RadojevićFull-back | CF Montreal | 🇷🇸Serbia | 22 | 10 | 0 | 1 | 6.4 | 6▲20.4%↩ | 39▲16%↩ |
| V. WanyamaCentral midfielder | CF Montreal | 🇰🇪Kenya | 35 | 0 | 0 | 0 | 0.3 | 0▼100% | 6▼68.6% |
| Vinícius NogueiraFull-back | Orlando City SC | 🇧🇷Brazil | 24 | 3 | 0 | 0 | 6.5 | 10▼63.5%↩ | 31▼32.8%↩ |
| Vítor CostaCentre-back | San Jose Earthquakes | 🇧🇷Brazil | 32 | 13 | 0 | 0 | 1 | 6▼60.3% | 12▼30.7% |