| K. PokuCentre-forward |  Vancouver Whitecaps | 🇨🇦Canada | 23 | 13 | 2 | 0 | 7.5 | 9▼26%↩ | 40▼9.6%↩ |
| C. DurkinCentral midfielder |  St. Louis City | 🇺🇸USA | 26 | 26 | 2 | 3 | 13.3 | 39▲186.1% | 40▲24.7% |
| O. UrhoghideFull-back |  FC Dallas | 🇳🇱Netherlands | 26 | 24 | 2 | 2 | 10.4 | 25▼5.7% | 41▲5.2% |
| A. QasemWinger |  Nashville SC | 🇸🇪Sweden | 23 | 22 | 2 | 1 | 7.4 | 16▲49.1% | 41▲3% |
| J. FerreiraAttacking midfielder |  Seattle Sounders | 🇺🇸USA | 25 | 21 | 2 | 4 | 7.7 | 24▼16.7% | 41▼7% |
| P. DithejaneFull-back |  Chicago Fire | 🇿🇦South Africa | 22 | 23 | 2 | 1 | 7.5 | 4▼79.1%↩ | 41▲72.1%↩ |
| H. SynchukCentral midfielder |  CF Montreal | 🇺🇦Ukraine | 20 | 20 | 2 | 1 | 6.8 | 21▲324% | 42▲4.5% |
| M. JimenezCentre-forward |  New York Red Bulls | 🏳️ | 18 | 6 | 2 | 0 | 5.7 | 8 | 42 |
| M. LongstaffCentral midfielder | CF Montreal | 🏴England | 26 | 29 | 2 | 3 | 9.9 | 37▲102.2%↩ | 42▲14.1%↩ |
| R. AlokoWinger |  Charlotte | 🏳️ | 16 | 19 | 2 | 2 | 5.2 | 9 | 42 |
| K. ThompsonFull-back |  Colorado Rapids | 🇨🇦Canada | 23 | 18 | 2 | 0 | 10.3 | 31▲51%↩ | 43±0% |
| Jude TerryAttacking midfielder |  Los Angeles FC | 🇺🇸USA | 18 | 12 | 2 | 1 | 6 | 7 | 43 |
| J. HaakDefensive midfielder |  Los Angeles Galaxy | 🇺🇸USA | 25 | 30 | 2 | 1 | 11.9 | 30▼27.5%↩ | 43▼3.6%↩ |
| L. SanabriaDefensive midfielder | Los Angeles Galaxy | 🇺🇾Uruguay | 22 | 29 | 2 | 1 | 8.9 | 35▲302.3% | 43▲14.8% |
| M. AgyemangCentre-back | Charlotte | 🇬🇭Ghana | 21 | 23 | 2 | 0 | 7.3 | 16 | 43 |
| J. ValienteAttacking midfielder | FC Dallas | 🇺🇾Uruguay | 25 | 28 | 2 | 9 | 10.2 | 31 | 44 |
| R. ElloumiCentre-forward | Vancouver Whitecaps | 🇨🇦Canada | 19 | 23 | 2 | 0 | 6.4 | 10▲104% | 44▲5.8% |
| K. FranklinFull-back |  Toronto FC | 🇨🇦Canada | 23 | 20 | 2 | 2 | 8 | 19▲119.3% | 44▲16.8% |
| R. Baker-WhitingFull-back | Nashville SC | 🇺🇸USA | 21 | 23 | 2 | 2 | 11.4 | 21▲165.8%↩ | 44▲8.9%↩ |
| M. WoledziCentre-back | Nashville SC | 🇬🇭Ghana | 25 | 30 | 2 | 0 | 14 | 61▲24%↩ | 45▲2.8%↩ |
| J. HopkinsCentral midfielder |  DC United | 🇺🇸USA | 22 | 30 | 2 | 1 | 7.7 | 30▲104.1% | 45▲13.8% |
| C. CowellWinger | New York Red Bulls | 🇺🇸USA | 23 | 28 | 2 | 6 | 8.2 | 29▲257.3%↩ | 46▼4.2%↩ |
| W. Frederick IICentral midfielder | Colorado Rapids | 🇺🇸USA | 22 | 26 | 2 | 2 | 9.2 | 34 | 47▲34.5% |
| R. DonkorCentral midfielder | New York Red Bulls | 🇲🇱Mali | 21 | 27 | 2 | 5 | 12 | 38▲137.3% | 48▲17.8% |
| É. OcampoFull-back | Vancouver Whitecaps | 🇨🇴Colombia | 23 | 26 | 2 | 1 | 14.6 | 54▲45.8% | 50▲8.1% |
| S. RodríguezAttacking midfielder |  Columbus Crew | 🇺🇾Uruguay | 26 | 8 | 2 | 2 | 7.9 | 20±0% | 52▼13.4%↩ |
| Y. DiabyCentre-forward | Vancouver Whitecaps | 🇬🇳Guinea | 26 | 8 | 2 | 1 | 6.7 | 38±0% | 55±0% |
| M. WhittakerWinger | Colorado Rapids | 🏴England | 25 | 6 | 2 | 0 | 6.7 | 48±0% | 72±0% |
| Josef MartínezCentre-forward | Columbus Crew | 🇻🇪Venezuela | 33 | 11 | 1 | 1 | 0.8 | 0▼100%↩ | 9▼45.6%↩ |
| M. MoralezAttacking midfielder |  New York City FC | 🇦🇷Argentina | 39 | 14 | 1 | 6 | 0.6 | 26▼39.8% | 9▼33.6% |
| K. SmithFull-back |  FC Cincinnati | 🇺🇸USA | 34 | 24 | 1 | 1 | 0.6 | 8▼35%↩ | 11▲1.9%↩ |
| F. HerbersCentre-forward | CF Montreal | 🇩🇪Germany | 33 | 19 | 1 | 0 | 0.7 | 7▲34.7% | 11▲2.9% |
| Ilie SánchezCentral midfielder |  Austin | 🇪🇸Spain | 35 | 24 | 1 | 0 | 1 | 17▼4.4% | 11▼9.6% |
| N. HagglundCentre-back | FC Cincinnati | 🇺🇸USA | 34 | 18 | 1 | 0 | 0.6 | 7▼58.4% | 13▼3.8% |
| A. GodoyCentral midfielder |  San Diego | 🇵🇦Panama | 36 | 28 | 1 | 1 | 1.2 | 20▼6.2% | 13▼4.4% |
| André GomesCentral midfielder | Columbus Crew | 🇵🇹Portugal | 33 | 22 | 1 | 0 | 1.5 | 18 | 14▲3.7%↩ |
| R. HollingsheadCentre-back | Los Angeles FC | 🇺🇸USA | 35 | 26 | 1 | 1 | 1.2 | 47▲38.1% | 14▼8.4% |
| K. RosenberryFull-back | Colorado Rapids | 🇺🇸USA | 32 | 18 | 1 | 1 | 1.7 | 12▲4.4% | 14▼4% |
| S. IbeaghaCentre-back | FC Dallas | 🇺🇸USA | 34 | 30 | 1 | 1 | 1.4 | 19▲1.1% | 15▼13.2% |
| H. LozanoWinger | Los Angeles Galaxy | 🇲🇽Mexico | 31 | 8 | 1 | 1 | 1.4 | 8▼81.8%↩ | 16▼34.3%↩ |
| L. AbubakarCentre-back | FC Dallas | 🇬🇭Ghana | 31 | 5 | 1 | 0 | 1.3 | 2▼85% | 16▼21.6% |
| J. WatermanCentre-back |  Portland Timbers | 🇨🇦Canada | 30 | 16 | 1 | 0 | 1.9 | 0▼100%↩ | 16▼35.9%↩ |
| W. ZimmermanCentre-back | Toronto FC | 🇺🇸USA | 33 | 22 | 1 | 0 | 1.7 | 24▲18.6%↩ | 16▲15.6%↩ |
| M. DeslerCentre-back | Austin | 🇩🇰Denmark | 31 | 19 | 1 | 0 | 2.1 | 11▼42.3% | 17▼14.4% |
| A. BouzatCentral midfielder |  Houston Dynamo | 🇦🇷Argentina | 32 | 25 | 1 | 1 | 2.4 | 23▼34.4%↩ | 18▼27%↩ |
| F. NegriCentre-back | Houston Dynamo | 🇦🇷Argentina | 31 | 18 | 1 | 0 | 2.5 | 17▲56.5%↩ | 18▼0.6%↩ |
| B. BronicoDefensive midfielder | Charlotte | 🇺🇸USA | 31 | 25 | 1 | 0 | 2.1 | 16▼51.6% | 18▼19.3% |
| T. BoydWinger | Los Angeles FC | 🇺🇸USA | 31 | 25 | 1 | 2 | 1.5 | 13▲456.5%↩ | 19▲32.2%↩ |
| J. StroudDefensive midfielder | DC United | 🇺🇸USA | 30 | 21 | 1 | 0 | 1.8 | 11▲50.7% | 20▼7% |
| J. PalaciosCentre-back | Nashville SC | 🇨🇴Colombia | 32 | 24 | 1 | 1 | 2.5 | 49▲112.5% | 20▲9.9% |
| H. ToffoloFull-back | Charlotte | 🏴England | 31 | 18 | 1 | 2 | 1.7 | 15▲127.7% | 20▲28.8% |
| A. Saint-MaximinWinger | Charlotte | 🇫🇷France | 29 | 12 | 1 | 3 | 4.4 | 4▼70.4%↩ | 22▼24.8%↩ |
| Sergi PalenciaFull-back | Los Angeles FC | 🇪🇸Spain | 30 | 15 | 1 | 1 | 3.2 | 21▼53.6% | 22▼25.1% |
| O. SvatokCentre-back | Austin | 🇺🇦Ukraine | 32 | 25 | 1 | 0 | 2.3 | 20▼22.4% | 22▲6.8% |
| J. YaroCentre-back | St. Louis City | 🇬🇭Ghana | 31 | 18 | 1 | 0 | 2.3 | 17▲70.4% | 22▼4.7% |
| S. SpieringsDefensive midfielder |  Real Salt Lake | 🇳🇱Netherlands | 30 | 21 | 1 | 1 | 3.6 | 28▲55.4%↩ | 23▲6.6%↩ |
| ReguilónCentre-back |  Inter Miami | 🇪🇸Spain | 29 | 16 | 1 | 0 | 2.5 | 6▲320%↩ | 24▼51.3%↩ |
| P. RuizCentral midfielder | Los Angeles Galaxy | 🇦🇷Argentina | 27 | 15 | 1 | 0 | 6.1 | 1▼95.2%↩ | 26▼15.7%↩ |
| A. SalétrosCentral midfielder | Chicago Fire | 🇸🇪Sweden | 30 | 25 | 1 | 1 | 3.9 | 17▼54.7%↩ | 27▲18.8%↩ |
| H. KesslerCentre-back | Charlotte | 🇺🇸USA | 28 | 14 | 1 | 0 | 3.2 | 8▼46.2%↩ | 27▼2.5%↩ |
| B. ByeFull-back | Portland Timbers | 🇺🇸USA | 30 | 20 | 1 | 3 | 2.3 | 11▼30.6%↩ | 27▲29%↩ |
| A. SalaouCentre-back | Toronto FC | 🇨🇮Côte d'Ivoire | 22 | 20 | 1 | 0 | 4.8 | 5▼40.7%↩ | 27±0% |
| K. MillerCentre-back | Portland Timbers | 🇨🇦Canada | 29 | 25 | 1 | 0 | 2.8 | 11▼33.7% | 27▼1.1% |
| C. McVeyCentre-back | San Diego | 🇸🇪Sweden | 29 | 25 | 1 | 0 | 4 | 31▼21.9% | 28▼15.5% |
| K. DuncanFull-back |  Minnesota United FC | 🇺🇸USA | 29 | 24 | 1 | 2 | 2.8 | 20▼15.6%↩ | 28▲4.8%↩ |
| Rafael SantosCentral midfielder | St. Louis City | 🇧🇷Brazil | 28 | 18 | 1 | 1 | 3.3 | 18▲61.6%↩ | 29▲1.4%↩ |
| T. BaumgartlCentre-back | St. Louis City | 🇩🇪Germany | 30 | 30 | 1 | 0 | 3.8 | 22▲28.7% | 29▲30% |
| A. GutmanFull-back | Chicago Fire | 🇺🇸USA | 30 | 22 | 1 | 4 | 2.7 | 23▼13% | 29▲0.7% |
| T. BlackmonCentre-back | Vancouver Whitecaps | 🇺🇸USA | 30 | 28 | 1 | 0 | 4.5 | 42▲47.7% | 30▲16.6% |
| K. HiebertCentre-back | St. Louis City | 🇨🇦Canada | 29 | 22 | 1 | 1 | 3.3 | 19▲24% | 31▼3.5% |
| S. KowalczykDefensive midfielder | Houston Dynamo | 🇵🇱Poland | 28 | 29 | 1 | 1 | 3.5 | 19▼32.7% | 32▼25.9% |
| J. BuenoDefensive midfielder |  Philadelphia Union | 🇻🇪Venezuela | 27 | 23 | 1 | 1 | 6.2 | 19▲49.2% | 32▲5.4% |
| S. MooreFull-back | FC Dallas | 🇺🇸USA | 30 | 29 | 1 | 2 | 5.5 | 26▲2.4% | 32▲2.3% |
| L. EngelCentre-back | Real Salt Lake | 🇩🇰Denmark | 27 | 14 | 1 | 0 | 6.6 | 9▼76.2%↩ | 32▼16.4%↩ |
| W. HarrisWinger |  New England Revolution | 🇺🇸USA | 26 | 13 | 1 | 0 | 6 | 4▲13.2%↩ | 32▲2.5%↩ |
| E. SaadWinger | Nashville SC | 🇹🇳Tunisia | 26 | 13 | 1 | 3 | 7.9 | 10▲7.6%↩ | 33▼33.7%↩ |
| M. NyemanCentral midfielder | Columbus Crew | 🇺🇸USA | 22 | 12 | 1 | 0 | 5.9 | 14▲4700%↩ | 33▼8.9%↩ |
| L. CampanaCentre-forward | New England Revolution | 🇪🇨Ecuador | 26 | 2 | 1 | 0 | 6.1 | 4▼84.4% | 33▼13.6% |
| L. JohnsenCentral midfielder |  Sporting Kansas City | 🇳🇴Norway | 27 | 23 | 1 | 1 | 9.3 | 24▼26%↩ | 33▲11%↩ |
| M. SuleymanovCentre-forward | Sporting Kansas City | 🇷🇺Russia | 26 | 24 | 1 | 1 | 6.1 | 12▼35% | 33▼8% |
| D. SchneggFull-back | Charlotte | 🇦🇹Austria | 28 | 20 | 1 | 4 | 3.7 | 12▼59.1%↩ | 33±0% |
| Matheus PereiraCentre-back | Toronto FC | 🇧🇷Brazil | 25 | 13 | 1 | 0 | 6.9 | 2▼80.8%↩ | 34▼35.3%↩ |
| D. PadelfordFull-back | New York Red Bulls | 🇺🇸USA | 23 | 18 | 1 | 1 | 8.7 | 1▼90.8%↩ | 34▼4.5%↩ |
| A. JabbariWinger | FC Cincinnati | 🇲🇦Morocco | 26 | 26 | 1 | 2 | 6.4 | 13 | 34▲14.8% |
| C. ClarkAttacking midfielder | Seattle Sounders | 🇺🇸USA | 23 | 13 | 1 | 0 | 7.2 | 2▼90%↩ | 34▼18.5%↩ |
| Kieran SargeantFull-back | San Diego | 🇺🇸USA | 23 | 21 | 1 | 1 | 7.5 | 14±0% | 34▲2.4%↩ |
| J. SandsCentre-back | New York City FC | 🇺🇸USA | 26 | 15 | 1 | 0 | 7.8 | 9▼68.6%↩ | 35▼44.7%↩ |
| M. FofanaCentre-back | New England Revolution | 🇲🇱Mali | 28 | 26 | 1 | 1 | 5.9 | 34▼23.8% | 35▲4.5% |
| R. RamosCentre-forward | Sporting Kansas City | 🇺🇸USA | 19 | 6 | 1 | 0 | 5.3 | 0 | 35±0% |
| A. SiebWinger | Los Angeles FC | 🇩🇪Germany | 23 | 8 | 1 | 0 | 7.5 | 0▼100%↩ | 35▼49.2%↩ |
| C. CappisCentral midfielder | FC Dallas | 🇺🇸USA | 27 | 30 | 1 | 1 | 8.2 | 22▲44.4% | 35▲13.2% |
| J. Sery LarsenCentre-back | Philadelphia Union | 🇩🇰Denmark | 26 | 14 | 1 | 0 | 7.9 | 14▲33.6%↩ | 35▼3.3%↩ |
| T. TillmanCentral midfielder | Los Angeles FC | 🇩🇪Germany | 27 | 19 | 1 | 2 | 6.5 | 27▲9.8% | 36▼4.3% |
| M. JakupovicWinger | Philadelphia Union | 🏳️ | 16 | 10 | 1 | 0 | 4.9 | 0 | 37 |
| J. ReynoldsFull-back | Sporting Kansas City | 🇺🇸USA | 22 | 16 | 1 | 2 | 7.5 | 8▲2600%↩ | 37▲1.6%↩ |
| C. HarperWinger | New York Red Bulls | 🇺🇸USA | 24 | 10 | 1 | 1 | 7 | 4▼71.1% | 37▼5.4% |
| B. BenderDefensive midfielder | Philadelphia Union | 🇺🇸USA | 25 | 11 | 1 | 0 | 6.8 | 13▲1333.3% | 37▲10.4% |
| B. VeraCentre-back | CF Montreal | 🇨🇴Colombia | 27 | 23 | 1 | 1 | 6.6 | 27▲28.6%↩ | 37▲8.8%↩ |
| A. AravenaCentral midfielder | Portland Timbers | 🇨🇱Chile | 24 | 19 | 1 | 0 | 7 | 8▼21%↩ | 37▼38.3%↩ |
| Wyatt MeyerCentre-back | Sporting Kansas City | 🇺🇸USA | 25 | 24 | 1 | 0 | 7.6 | 13▲746.7%↩ | 38▲13%↩ |
