| 1 | S. BerhalterDefensive midfielder | Vancouver Whitecaps | 25 | 56▲106.3% | 49▲13.5% |
| 2 | M. ArfstenDefensive midfielder | Columbus Crew | 25 | 49▲86.9% | 47▲0.6% |
| 3 | E. LöwenDefensive midfielder | St. Louis City | 29 | 45▲33.4% | 30▼15.9% |
| 4 | C. RoldanDefensive midfielder | Seattle Sounders | 31 | 42▲27.4% | 25▼19.7% |
| 5 | J. OsorioDefensive midfielder | Toronto FC | 34 | 41▲107.5% | 17▼6.2% |
| 6 | D. AyalaDefensive midfielder | Portland Timbers | 23 | 40▲62.2% | 45▲9.1% |
| 7 | A. PereaDefensive midfielder | New York City FC | 25 | 37▲74.3% | 43▲4.1% |
| 8 | D. ChambostDefensive midfielder | Columbus Crew | 28 | 36▲309% | 35±0% |
| 9 | P. BuchaDefensive midfielder | FC Cincinnati | 28 | 35▼11.9% | 35▼20.5% |
| 10 | M. HerreraDefensive midfielder | Columbus Crew | 27 | 34▲22.2% | 36▼25.4% |
| 11 | A. CubasDefensive midfielder | Vancouver Whitecaps | 30 | 34▲13.6% | 27▼12.5% |
| 12 | A. WestwoodDefensive midfielder | Charlotte | 36 | 33▲5.4% | 18▼1.6% |
| 13 | O. LarrazDefensive midfielder | Colorado Rapids | 24 | 32▲4.9% | 43▼0.7% |
| 14 | J. AtencioDefensive midfielder | Colorado Rapids | 24 | 32▲102.6% | 41▲5.9% |
| 15 | C. BassettDefensive midfielder | Colorado Rapids | 24 | 31▼16.5% | 46▼2.9% |
| 16 | Alonso CoelloDefensive midfielder | Toronto FC | 26 | 31▲23.1% | 39▼4.4% |
| 17 | V. LoturiDefensive midfielder | CF Montreal | 25 | 31▲1300% | 42▲12.6% |
| 18 | M. PolsterDefensive midfielder | New England Revolution | 33 | 31▲19.1% | 17▼24.3% |
| 19 | Igor JesusDefensive midfielder | Los Angeles FC | 23 | 30▲214.6% | 46▼14.4% |
| 20 | H. LandryDefensive midfielder | Charleston Battery | 25 | 28 | 41 |
| 21 | P. StroudDefensive midfielder | New York Red Bulls | 24 | 28▲137.9% | 43▲8.7% |
| 22 | N. CaliskanDefensive midfielder | Real Salt Lake | 25 | 27▲1185.7% | 40▲13.9% |
| 23 | B. OjedaDefensive midfielder | Real Salt Lake | 26 | 27▼25.7% | 38▼17% |
| 24 | A. MolloyDefensive midfielder | Charleston Battery | 29 | 25 | 27 |
| 25 | O. ValenciaDefensive midfielder | New York Red Bulls | 22 | 25 | 43▲19.2% |
| 26 | D. EdelmanDefensive midfielder | New York Red Bulls | 23 | 25▲12.7% | 43▼6.9% |
| 27 | A. FortuneDefensive midfielder | Atlanta United FC | 23 | 24▲28.4% | 42▼1.4% |
| 28 | Z. BassongDefensive midfielder | Sporting Kansas City | 27 | 24▲177.3% | 32▼13.3% |
| 29 | O. NwobodoDefensive midfielder | FC Cincinnati | 29 | 24▼15.7% | 27▼27.8% |
| 30 | A. RebollarDefensive midfielder | Monterey Bay | 26 | 23 | 35 |
| 31 | Y. BrightDefensive midfielder | Inter Miami | 24 | 23±0% | 39▼12.9% |
| 32 | J. BartlettDefensive midfielder | Sporting Kansas City | 20 | 22 | 41 |
| 33 | B. AnungaDefensive midfielder | FC Cincinnati | 29 | 22▲45.8% | 27▼11.7% |
| 34 | D. CharáDefensive midfielder | Portland Timbers | 40 | 22▼4.9% | 8▼33.3% |
| 35 | F. CarballoDefensive midfielder | New York Red Bulls | 29 | 22▲83.8% | 26▼14.3% |
| 36 | S. DjeffalDefensive midfielder | Lexington | 27 | 21▲863.6% | 32▼6.9% |
| 37 | E. EcheniqueDefensive midfielder | FC Cincinnati | 22 | 21 | 41 |
| 38 | C. DurkinDefensive midfielder | St. Louis City | 26 | 20▼33.6% | 34▼20.1% |
| 39 | D. CrisostomoDefensive midfielder | Tampa Bay Rowdies | 29 | 19▲717.4% | 24▼20.3% |
| 40 | A. WattsDefensive midfielder | St. Louis City | 26 | 19▲43.1% | 34▼8.4% |
| 41 | B. DialloDefensive midfielder | FC Tulsa | 23 | 18 | 42 |
| 42 | M. LongstaffDefensive midfielder | Toronto FC | 26 | 18▼36.1% | 37▼11.1% |
| 43 | M. KayeDefensive midfielder | San Jose Earthquakes | 31 | 18▲17.4% | 17▼28.6% |
| 44 | A. MoralesDefensive midfielder | St. Louis City | 36 | 18▲302.2% | 11▲31.3% |
| 45 | R. DonkorDefensive midfielder | New York Red Bulls | 21 | 18▲117.1% | 42▲2.7% |
| 46 | D. DianiDefensive midfielder | Charlotte | 28 | 18▼30.7% | 28▼24.9% |
| 47 | D. MarczukDefensive midfielder | Real Salt Lake | 22 | 18▲182.3% | 42▲4% |
| 48 | S. PietteDefensive midfielder | CF Montreal | 31 | 17▼39.6% | 20▼29.4% |
| 49 | A. O'NeillDefensive midfielder | New York City FC | 28 | 16▼27.8% | 30▼38.5% |
| 50 | D. MercadoDefensive midfielder | Miami FC | 29 | 15▲3600% | 25▼37.8% |